- Over the years, we have developed a diverse range of non-conventional modification strategies for natural nucleoside compounds, including stereoselective and enantioselective transformations. Our expertise lies in designing efficient, stereochemically controlled synthetic methodologies tailored to complex molecular architectures
- Leveraging our deep expertise in synthetic methodologies, multi-step syntheses and experience with advanced techniques in nucleoside and nucleotide chemistry, we are well-positioned to support the synthesis of challenging compounds to meet your research objectives
- We utilize reversed-phase chromatography, and Sephadex or polystyrene resin-based techniques for the purification of nucleosides and nucleotides. Purity is assessed through HPLC using dedicated columns, while structural elucidation is performed via mass spectrometry and NMR analysis
Nucleosides & Nucleotides
Our expertise comprises
Novel Nucleobases
Modified Sugar Cores
Novel Nucleosides
Morpholino Nucleobases
GalNac Molecules
Prodrugs
Cap Reagents
Custom Building Blocks for Oligonucleotides
- Chemveda, offers specialized expertise in the synthesis, analysis, and custom modification of nucleosides, nucleotides, and their analogs. Committed to the highest standards of quality, innovation, and client-focused service, we provide advanced solutions that support and accelerate your research
- Our expertise spans the full spectrum of nucleoside and nucleotide chemistry, enabling us to meet your specific requirements with reliability and efficiency. Whether the project involves custom synthesis or scale-up, our experienced team of scientists is fully equipped to support your research goals
- Our dedicated team brings over a decade of deep expertise in the synthesis of nucleosides and nucleotides, ensuring reliable and high-quality results across a wide range of applications
Expertise and Experience
Custom Nucleoside
and Nucleotide Synthesis
and Nucleotide Synthesis
- Custom Synthesis of modified Nucleosides and Nucleotides with novel protecting groups in mg to tens of gram quantities
- Synthesis at the scales and purity of your specifications in a cost-effective and timely manner
Our Key Capabilities
Nucleoside Analogues
+
_
- Modifications of nucleobases to fit your research needs
- Synthesis of new nucleobases of interest with novel protecting moieties
- Synthesis of novel C-nucleosides and N-nucleosides
- LNA nucleosides
- Bicyclic nucleosides
- Carbocyclic nucleosides, acyclic nucleosides
Modified Sugars
+
_
- Modifications and substitutions on sugar core of nucleosides
- Modified sugar cores such as aza-, thia-, carba-sugars and corresponding nucleosides
- Modifications/Substitution on the sugar at different positions, viz., 2’-, 3’-, 4’-, and 5’- of the nucleoside
- Synthesis of non-natural sugars and Modified phosphate sugars
Modified Phosphate Backbone Components
+
_
Synthesis of modified monomers for backbone-modified oligonucleotides such as Phosphorothioates, Phosphorodithioates, methyl phosphonates
Building Blocks for Oligonucleotides
+
_
- Nucleoside scaffolds/building blocks
- Modified nucleoside Phosphoramidites
- mRNA monomers and capped analogs
- GalNac derivatives
Phosphorylation Strategies
+
_
Synthesis of nucleoside monophosphates, nucleoside diphosphates and nucleoside triphosphates
Prodrug Synthesis
+
_
Phosphoramidate synthesis (ProTide technology)
LET’S COLLABORATE Accelerating Chemistry
Breakthroughs
Breakthroughs