- Our highly skilled chemistry team has extensive experience in the synthesis of a broad range of linkers and payloads providing robust and sustained support for antibody-drug conjugate (ADC) research and development
- We have deep expertise in the development of ADC constructs incorporating hydrophilic functionalities, charged groups, click chemistry handles, and bio-orthogonal linkers. These capabilities support in-depth SAR studies aimed at optimizing payload potency, linker length and cleavability
- Hands on experience with the synthesis of novel short peptide linkers and respective payload-peptide constructs containing tailored self-immolative moieties (payload release component)
ADC Linker-payloads
Our expertise comprises
Synthesis of ADC Payloads
Synthesis of ADC Linkers
Payload-Linker Complexes
- Leveraging our expertise in supporting discovery programs for small molecules and harnessing our expertise in the synthesis of complex molecules and peptide chemistry, we have been successfully delivering projects in the ADC space
- We have extensive experience in the synthesis of a broad range of linker-payload constructs to support SAR studies. We also bring deep expertise in the synthesis of Auristatins (MMAE, MMAF), camptothecins, calicheamicins and custom payloads enabling discovery stage programs to efficiently explore novel conjugation strategies and payload modalities
- We have expertise incorporating modifications to modulate the hydrophobicity of linkers; where modifier components such as sugars, polyethylene glycol (PEG), polysarcosine (PSAR), sulfonates, hydrophilic macrocycles such as cyclodextrins, crown ethers etc., are incorporated as per the requirements of our clients
Our Expertise
Custom ADC
Linker-Payload
Synthesis Services
Linker-Payload
Synthesis Services
We offer custom synthesis of novel ADC linkers and high-quality linker-payload constructs with specialized expertise in optimizing both novel and existing payloads to align with the specific requirements of the discovery project.
Linker-Payload Synthesis Capabilities
Synthesis of Novel Linkers
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- ADC linker development services including the synthesis of designed/tailored linkers, characterization and optimization
- Cleavable linkers
- Acid-labile linkers
- Peptide based inkers
- Disulfide linkers
- Glucuronide based linkers
- Non-cleavable linkers
- Modified linkers (hydrophilic linkers)) containing PEGs, sugars, cyclodextrin
Synthesis of Payloads
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- Design efficient synthetic routes, synthesize, characterize innovative ADC payloads
- Synthesize analogues for SAR development
Synthesis of Drug-Linker Complexes
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- Synthesis of customized drug-linker complexes
- Construction of customized entities to create IP opportunities
LET’S COLLABORATE Accelerating Chemistry
Breakthroughs
Breakthroughs