- Our team has extensive experience in the synthesis of anchoring ligands and bifunctional molecules essential for the development of novel targeted protein degraders, including PROTACs and molecular glues
- We leverage our expertise in Staudinger ligation chemistry, solid-phase synthesis and click chemistry to enable the efficient and modular construction of PROTACs and other bifunctional degraders
- Extensive experience in the synthesis of small molecules serving as ligands for proteins of interest, enabling their use in targeted protein degradation
- Synthetic chemistry expertise in the synthesis (often multi-step) of heterobifunctional molecules with multiple functional handles
Targeted Protein Degraders
Our expertise includes
Bifunctional Protein Degrader molecules and their components
Molecular Glues
PROTACs
Linkers
Target-binding Warheads
- At Chemveda, we are committed to advancing the field of PROTAC (Proteolysis Targeting Chimera) technology. Collaborating closely with leading researchers, we deliver high-quality, potent, and selective PROTACs engineered for specific therapeutic targets to accelerate your research in targeted protein degradation. (TPD)
- Our extensive expertise in heterocyclic chemistry and asymmetric synthesis enables the efficient synthesis of novel warheads, inhibitors in milligram to gram scales supporting early-stage discovery
- We utilize flash chromatography, prep-HPLC and chiral-SFC for purification, 1H-NMR and mass spectrometry for characterization and HPLC for purity assessment
Our Experience and Expertise
Custom PROTAC
Synthesis Services
Synthesis Services
- Chemveda provides a comprehensive suite of PROTAC synthesis services, including the development of novel PROTACs, partial PROTACs, and ligands. Chemveda provides end-to-end custom synthesis services for bifunctional molecules
- With a strong track record in synthesizing challenging compounds, we offer our PROTAC discovery synthesis from milligrams to grams with high purity
Heterobifunctional Degrader Synthesis Capabilities
Synthesis of PROTACs/Molecular Glues
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Synthesis and purification of different types of PROTACs and partial PROTACs, novel degrader building blocks in milligram to gram quantities.
Synthesis of E3-ligase Ligands
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Synthesis and functionalization of various E3-ligase ligands such as CRBN, VHL, MDM2 and clAP1 (in multi-gram scale)
Synthesis of Linker Structures
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- Synthesis of novel linkers-both flexible and rigid linkers, PEG based linkers of varying length, hydrophobicity and composition
- Synthesis of tailored linkers or hybrid designs to suite your project needs
- Synthesis support for the optimization of linker types and size, linker-anchor or linker-recruiter connection
Synthesis of Target-binding Ligands/Warheads
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- Design and synthesis of ligands for the protein of interest (POI)
- Optimization of functional groups on the ligands of interest for linker attachment (SAR support)
Synthesis of other Degrader Molecules
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Synthesis of bifunctional molecules for other degradation technologies such as AUTACs, LYTACs, etc.
LET’S COLLABORATE Accelerating Chemistry
Breakthroughs
Breakthroughs