- We have broad experience and strong expertise in heterocyclic, chiral and complex molecule synthesis, metal-mediated transformations, as well as parallel synthesis capabilities for rapid analog generation
- We have expertise in identifying efficient synthetic pathways (route scouting) and optimizing for yield, purity, scalability and cost
Synthetic Chemistry
Heterocycles
Asymmetric Synthesis
Specialty Chemistry
Stable isotope-labelled compounds
Natural Products Synthesis
Molecular Probes
- The Chemveda team has built a strong reputation as a reliable partner for our customers based on deep knowledge of synthetic chemistry. We have been able to solve many complex synthetic challenges with exceptional ideas that led to great results adding value to the projects
- We have been providing a comprehensive range of chemistry services in the discovery stages including during hit validation, hit-to-lead identification, lead optimization, hit/fragment expansion, property optimization, SAR development, and bioisosteric replacement strategies. Working closely with our scale-up, process development and manufacturing groups, we enable a speedy advancement of compounds. The dynamic team at Chemveda always strives to contribute the best to your research
- We routinely generate final target molecules, create building blocks, scaffolds and intermediates. Outside of standard small molecule heterocyclic chemistry, our seasoned chemists also have expertise across a wide range of specialty chemistry platforms including nucleosides, nucleotides, peptides, molecular glues and PROTACs, ADC linkers, payloads and molecular probes (biotinylated targets and fluorophores) to just name a few
Synthetic Chemistry Expertise
Scale-up capabilities
- The discovery chemistry team has capabilities to scale up to larger amounts (mg to hundreds of grams) for target molecules, building blocks and intermediates
- For large scale needs (kilo to multi-kilogram) the discovery team will work closely with our scale-up and process development teams to ensure the efficient transfer of working knowledge between the teams in a short time period thus minimizing time and cost
Synthetic Chemistry Core Capabilities and Equipment
Multi-step syntheses
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We have a strong track record of conducting a diverse array of chemistry projects encompassing the synthesis of complex heterocyclic compounds, natural products, peptides, nucleosides and nucleotides on scales ranging from milligram to kilogram quantities. Many of these syntheses involve multi-step synthetic routes, demonstrating our capability in handling complex and challenging chemistries.
(https://doi.org/10.1021/jacs.0c03592;https://doi.org/10.1002/chem.202301938)
Parallel & Library Chemistry
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We have strong expertise in focused library design and production to support rapid SAR development. LC-MS data will be provided for all library compounds and 1H-NMR data for representative/selected compounds. The building blocks utilized may be natural product based, sourced commercially, or synthesized in-house. For in-house synthesized building blocks, comprehensive characterization data is provided.
Isotopic Labelling Services
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We have rich experience in the synthesis of stable isotope-labelled compounds. Isotopes we have worked with include Carbon-13 (13C), Nitrogen-15 (15N), and Deuterium (2H). Analytical techniques such as LC-MS, 2D-NMR are employed to elucidate the structure of compounds and to provide a certificate of analysis wherever required.
Photoredox chemistry
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We have a well-established track record in employing visible-light photoredox catalysis to perform complex chemical transformations. Our team possesses deep expertise in photoredox catalyzed transformations mediated by transition metal complexes and organic dye molecules. (https://doi.org/10.1039/D4NJ04300F)
Natural product synthesis
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At Chemveda, we relish working on challenging projects. Complex natural products have been synthesized at scales and purity according to customer’s specifications. High-yielding synthetic strategies and purification technique were developed to deliver some of the complex natural products.
Chiral synthesis or Asymmetric synthesis
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We have broad experience and strong expertise in the methods used in asymmetric synthesis to achieve enantioselectivity. Our team of skilled scientists has successfully employed the following techniques to deliver enantiomerically pure compounds to meet our customer’s specific project requirements.
- Chiral Pool Synthesis
- Chiral Auxiliaries
- Chiral Reagents
- Chiral Catalysts
- Asymmetric Induction
Resolution of Racemates: via classical resolution methods, derivatization methods and or chiral prep-HPLC or SFC
Electrochemistry
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We have expertise using ElectraSyn 2.0 to access unique reactions (https://doi.org/10.1021/acs.orglett.4c00474).
We also have extensive experience in flow-electrochemistry, enabling efficient and scalable synthesis of otherwise difficult to access target compounds
LET’S COLLABORATE Accelerating Chemistry
Breakthroughs
Breakthroughs